Research Journal of Pharmacology and Pharmacodynamics

Pankaj Rakha ¹, Manju Nagpal ¹, Sunil Sharma ², Milind Parle ²

Affiliations
1 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa - 125055, IN
2 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN

Abstract

In the present study the ethanolic fraction of seeds of the plant Ocimum basilicum Linn. was taken and its anti-inflammatory potential was evaluated using carrageenan and formalin induced rat paw edema. The effect on chronic phase of inflammation was also studied using cotton pellet granuloma technique. The increase in paw thickness was measured using digital vernier caliper after 1,2,3 and 4 h of injection. Ethanolic fraction of the seeds of the plant at dose of 400 mg/Kg significantly inhibited acute phase of inflammation. The decrease in the weight of granuloma was also found by ethanolic fraction of the seeds at same dose. The study reveals that the ethanolic fraction of seeds of Ocimum basilicum Linn. possesses significant anti-inflammatory activity.

Keywords

Anti-Inflammatory, Carrageenan, Formalin, Granuloma.

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